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Research

Study to Determine the Safety of Two Applications of PEP005 Topical Gel to Cutaneous Squamous Cell Carcinoma In Situ

24 Sep 2007
The purpose of this study is to determine whether the topical application of PEP005 is safe and effective for the treatment of cutaneous squamous cell carcinoma in situ (SCCIS, Bowen's disease). › More

Study to Compare the Efficacy and Safety of CC-5013 Vs. Placebo in Subjects With Metastatic Malignant Melanoma.

6 Sep 2007
Subjects are randomized to one of two treatment arms. All subjects are screened for eligibility within 28 days prior to randomization. The study consists of a treatment phase and a follow-up phase. ... › More

Metvix PDT in Patients With "High Risk" Basal Cell Carcinoma

29 Aug 2007
The variable "complete response" after one or two Metvix treatment cycles will be used as the basis for the justification of sample size. The following hypothesis will be tested: H0: Complete ... › More

Safety Study of Herpes Simplex Vaccine in HSV Seronegative and Seropositive Females Between 10 and 17 Years Old

23 Jul 2007
Main goal of this study is to compare the occurrence of serious adverse events (SAEs) between the herpes simplex (gD2-AS04) vaccine group and the Saline control group throughout the study period (up ... › More

Study of "NY-ESO-1 ISCOMATRIX" in Patients With High-Risk, Resected Melanoma

11 Jul 2007
The purpose of this trial is to assess whether treatment with "NY-ESO-1 ISCOMATRIX" vaccine improves outcomes for people with Malignant Melanoma which has been removed, but is at high risk of ... › More

Study to Evaluate the Efficacy of the Human Papillomavirus Vaccine in Healthy Adult Women of 26 Years of Age and Older.

26 Jun 2007
This study will evaluate the immune responses, safety and efficacy of the investigational HPV vaccine in women who are 26 years of age or older. Infection with human papilloma virus (HPV) has been ... › More

Study to Determine the Safety of Two Applications of PEP005 Topical Gel to Nodular Basal Cell Carcinoma.

15 May 2007
The purpose of this study is to determine whether topical application of PEP005 is safe for the treatment of nodular basal cell carcinoma. › More

Vaccine Therapy for Patients With Stage III Melanoma

8 Apr 2007
This is a Phase 3 study in patients with melanoma that has spread to the lymph nodes (stage III), and who have had all of their cancer surgically removed. The purpose of this study is to evaluate the ... › More

Formation and Severity of Pressure Ulcers Associated With 4% Albumin Vs. 0.9% Sodium Chloride

21 Mar 2007
Pressure ulcers incur multiple risks to the patient. The disruption of the skin is a portal of entry for infection, which may remain localised to the site or become blood borne. A pressure ulcer can ... › More

Intralesional PV-10 Chemoablation of Metastatic Melanoma

28 Feb 2007
The objective of this study is to investigate the safety of intralesional (IL) PV-10 for the treatment of metastatic melanoma. This study will also include a preliminary assessment of response of ... › More

Trials

A Safety Study of Two Intratumour Doses of Coxsackievirus Type A21 in Melanoma Patients.

27 Sep 2007
The purpose of the study is to determine the safety and tolerability of two doses of Coxsackievirus A21, administered 48 hours apart into a superficial melanoma tumour. Injected and non-injected ... › More

Isavuconazole in the Treatment of Candidemia and Other Invasive Candida Infections

3 Sep 2007
The purpose of the study is to compare the safety and efficacy of Isavuconazole versus caspofungin followed by voriconazole in the treatment of candidemia and other invasive Candida infections. › More

A Study of BMS-582949 in Patients With Moderate to Severe Plaque Psoriasis

26 Aug 2007
The purpose of this clinical research study is to learn if BMS-582949 alone is an effective treatment for moderate to severe psoriasis. The safety of the drug and the effectiveness of each dose will ... › More

A Study of LY573636 in Treating Patients With Malignant Melanoma

10 Aug 2007
The primary objective of this study is to determine the objective response rate (complete and partial response) for patients who receive LY573636 after one prior systemic treatment for unresectable ... › More

Post-Operative Concurrent Chemo-Radiotherapy Versus Post-Operative Radiotherapy for Cancer of the Head and Neck

31 Jul 2007
The primary objective of the trial is to determine, in patients who have undergone surgery with curative intent for high-risk cutaneous squamous cell carcinoma (CSCC) of the head and neck, whether ... › More

PI-88 and/or Dacarbazine in Treating Patients With Metastatic Melanoma That Cannot Be Removed By Surgery

15 Jun 2007
PI-88 may stop the growth of tumour cells by blocking blood flow to the tumour. Drugs used in chemotherapy, such as dacarbazine, work in different ways to stop the growth of tumour cells, either by ... › More

A Study of the Effectiveness of Virtual Reality Relaxation Combined With Patient-Controlled Analgesia (PCA) Morphine for Those Undergoing Burn Dressing Changes

14 May 2007
The purpose of this study is to evaluate whether a sub-population of patients with burn injuries needing dressing changes respond to virtual reality (VR) utilising relaxation themes with improved ... › More

The Efficacy of a Pseudoallergen-Free Diet in the Treatment of Chronic Idiopathic Urticaria and/or Angioedema

11 May 2007
This study involves investigating the effects of a pseudoallergen-free (active) diet compared with a control (placebo) diet in the treatment of Chronic Idiopathic Urticaria (CIU) and/or Angioedema. ... › More

Study Evaluating Etanercept on Skin and Joint Disease in Psoriatic Arthritis

6 Apr 2007
To assess the efficacy of two different treatment regimens of etanercept in psoriasis subjects with psoriatic arthritis with respect to both the skin and joint manifestations. › More

Prevention of Asthma With Levocetirizine (36 Month Treatment) in Young Children Suffering From Eczema (Atopic Dermatitis) and Sensitized to Grass Pollen and House Dust Mite and Having Completed the Previous EPAAC Trial

16 Mar 2007
36 months study to evaluate the efficacy and safety of levocetirizine (LCTZ) in preventing the onset of asthma in young atopic children. › More

The support of the following commercial entities are greatfully acknowledged: